I had the same problem using a logitech ps/2 mouse with an OmniView 4-port KVM switch.  Using computer #3 without computer #1 running caused this problem for some reason.  Changing the switch ports seems to have solved it.

Timothy Wilson wrote:
>Hey everyone,

>Anybody had trouble with a Logitech optical mouse (using PS/2 adaptor),
>XFree 4.1.0, and a Matrox G450? I've got X configured and displaying
>properly, but I have trouble with my mouse pointer jumping randomly around
>the screen, buttons apparently being pushed 

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